Medications work in a number of different ways. Some medications block the protein (enzyme) that breaks down acetylcholine (needed for muscle contraction). Others suppress the body’s immune system reducing antibodies which attack the muscle as explained in Week 1. Let’s learn more about these medications.
In this section we will learn about the following medical treatments:
Anti-acetylcholinesterase agents
Neonatal Fc receptor (FcRn) blockers
C5 Protein Inhibitors
Corticosteroids and immunosuppressant agents
1. Anti-acetylcholinesterase agents
Mestinon® (pyridiostigmine bromide): Helps acetylcholine, a chemical in our body, work better by letting it stay active longer. This improves muscle strength. It comes as fast-acting 60 mg tablets or slow-release 180 mg capsules called Timespan®.
2. Neonatal Fc receptor (FcRn) blockers
VYVGART® (efgartigimod alfa-fcab): Approved for adults with a specific type of MG. It's given as a weekly 1-hour infusion for 4 weeks, then repeated. VYVGART works by getting rid of harmful antibodies causing MG symptoms. There's also an injection version called VYVGART® Hytrulo.
RYSTIGGO® (rozanolixizumab-noli): Approved for adults with both main types of MG. It's an antibody that helps reduce certain harmful antibodies in the body. RYSTIGGO is given as an injected infusion under the skin (subcutaneously). RYSTIGGO is unique in treating both anti-AChR and anti-MuSK antibody-positive MG.
3. C5 Protein Inhibitors
Ultomiris® (ravulizumab-cwvz): Helps 80% of MG patients by blocking a protein that makes the body attack itself. It's given as an IV every eight weeks. It has shown good results in improving daily activities and is convenient with less frequent dosing.
4. Corticosteroids and Immunosuppressants
Medications like Prednisone, Imuran® (azathioprine), Cellcept® (mycophenolate), or Cyclosporin® might be prescribed. They work by reducing the body's harmful antibodies that cause MG symptoms. They can be taken alone or mixed.
These are just some of the medications available to help treat MG. In the next section, we explore even more options.
You can read more information here
Disclaimer
Content has been taken from MGFA, adapted and clinically reviewed for accuracy.